"Not Responding"

I am multi tasking at work with my beloved laptop, but now allot of applications are saying "Not Responding", as I have over loaded it with allot of applications been open, such was outlook, TeamMate, ACL and MS Excel. Now its crying out loud, "You are killing me," I am not, allot of people are waiting for the outcome of my work, I have to complete it before 3 to go for the GYM.